While susceptibility to infections is a hallmark of PIDs, some children may present with noninfectious symptoms. These manifestations include:

• Recurrent Infections: Frequent bacterial, viral, or fungal infections affecting various organs.
• Failure to Thrive: Poor growth and development due to chronic illness.
• Autoimmune Features: Examples include autoimmune cytopenias (e.g., autoimmune hemolytic anemia) and inflammatory skin conditions.
• Lymphoproliferation: Abnormal expansion of lymphocytes.
• Allergic Disorders: Some PIDs are associated with allergies and atopic conditions.